COBRE Funded Publications Published by COBRE Graduates

Publications resulting rom the COBRE grant as of October 1, 2010

Jong Seop Rim, PhD

Axin expression in thymic stromal cells contributes to age-related increase in thymic adiposity and associated with reduced thymopoiesis independently of ghrelin signaling.
Yang H, Youm Y-H, Sun Y, Rim JS, Galban C, Bolormaa Vandanmagsar B, Dixit VD.
J Leukoc Biol 2009;85(6):928-38.PMCID:PMC2718808.

Beta(3)-adrenergic signaling acutely down regulates adipose triglyceride lipase in brown adipocytes.
Deiuliis JA, Liu L, Belury MA, Rim JS , Shin S, Lee K.
Lipids 2010;45(6):479-89. PMC Journal – In Process.

Screening for epigenetic target genes that enhance reprogramming using lentiviral delivered shRNA.
Rim JS, Strickler K, Harkins L, Barns C, Power R, J. Eilertsen KJ.
Methods Mol Biol. 2011; 702:299-316. PMC Journal – In Process.

Robert Koza, PhD

Inter-individual variation of dietary fat-induced mesoderm specific transcript in adipose tissue within inbred mice is not caused by altered promoter methylation.
Koza RA, Rogers P, Kozak LP.
Epigenetics 2009;4(7):512-518. PMCID In Process.

The early nutritional environment of the mouse determines the capacity for adipose tissue expansion by modulating genes of caveolae structure.
Kozak LP, Newman S, Chao P-M, T. Mendoza T, Koza RA.
PLoS One 2010;5(6):e11015. PMCID:PMC2888576.

Barbara Gawronska-Kozak, PhD

Ear mesenchymal stem cells (EMSC) can differentiate into spontaneously contracting muscle cells.
Gawronska-Kozak B, Manuel JA, Prpic V. J Cell Biochem 2007 Sep 1;102(1):122-35.

Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice.
Gao Z, Wang Z, Zhang X, Butler AA, Zuberi A, Gawronska-Kozak B, Lefevre M, York D, Ravussin E, Berthoud HR, McGuinness O, Cefalu WT, Ye J. Am J Physiol Endocrinol Metab 2007 Jan;292(1):E84-9.

Role of adiponectin and inflammation in insulin resistance of Mc3r and Mc4r knockout mice.
Trevaskis JL, Gawronska-Kozak B, Sutton GM, McNeil M, Smith SR, Butler AA.
Obesity 2007 Nov;15(11):2664-72.

Stem cell antigen-1 positive ear mesenchymal stem cells (EMSC) display enhanced adipogenic potential.
Staszkiewicz J, Gimble J, Manuel J, Gawronska-Kozak B.
Stem Cells 2008 Oct;26(10):2666-73. PMCID:PMC2761741.

Flow cytometric and immunohistochemical detection of in vivo BrdU-labeled cells in mouse fat depots.
Staszkiewicz J, Gimble J, Cain C, Dietrich M, Burk D, Kirk-Ballard H, Gawronska-Kozak B.
Biophys Res Commun 2009;378:539-544. PMCID:PMC2731488.

Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure.
Tang T, Zhang J, Yin J, Staszkiewicz J, Gawronska-Kozak B, Jung DY, Ko HJ, Ong H, Kim JK, Mynatt R, Martin RJ, Keenan M, Gao Z, Ye J.
J Biol Chem 2010 Feb 12;285(7):4637-44. PMCID:PMC2836069.

Cell growth characteristics, differentiation frequency and immunophenotype of adult ear mesenchymal stem cells.
Staszkiewicz J, Frazier TP, Rowan BG, Bunnell BA, Chiu ES, Gimble JM, Gawronska-Kozak B.
Stem Cells Dev 2010 Jan;19(1):83-92. PMC-Journal - In Process.

Flow cytometric and immunohistochemical detection of in vivo BrdU-labeled cells in mouse fat depots.
Staszkiewicz J, Gimble J, Cain C, Dietrich M, Burk D, Kirk-Ballard H, Gawronska-Kozak B.
Biophys Res Commun 2009;378:539-544. PMCID:PMC2731488.

Elizabeth Floyd, PhD

Degradation of STAT5 Proteins in 3T3-L1 Adipocytes is induced by TNF and cycloheximide in a manner independent of STAT5A activation.
Floyd ZE, Segura BM, He F, Stephens JM.
Am J Physiol Endocrinol Metab 2007;292(2):E461-8.

Secretome of primary cultures of human adipose-derived stem cells: modulation of serpins by adipogenesis.
Zvonic S, Lefevre M, Kilroy G, Floyd ZE, Delany JP, Kheterpal I, Gravois A, Dow R, White A, Wu X, Gimble JM.
Mol Cell Proteomics 2007;6(1)18-28.

The modulation of STAT5/GR complexes during fat cell differentiation and in mature adipocytes.
Baugh JE, Floyd ZE, Stephens JM.
Obesity 2007;15(3):583-90.

Effects of prolyl hydroxlyase inhibitors on adipogenesis and hypoxia inducible factor 1 alpha levels under normoxic conditions.
Floyd ZE, Kilroy SG, Wu X, Gimble JM.
J Cell Biochem 2007;101(6):1545-57.

Induction of circadian gene expression in human subcutaneous adipose-derived stem cells.
Wu X, Zvonic S, Floyd ZE, Kilroy G, Goh BC, Hernandex TL, Eckel RH, Mynatt RL, Gimble JMbr /> Obesity 2007;15(11):2560-2570.

Circadian Rhythms and the Regulation of Metabolic Tissue Function and Energy Homeostasis.
Zvonic S, Floyd ZE, Mynatt RL, Gimble JM.
Obesity 2007;15(3):539-43.

Combustion-derived hydrocarbons concentrate in cytoplasmic lipid droplets of respiratory cells.
Murphy G Jr, Rouse RL, Polk WW, Henk WG, Barker SA, Boudreaux MJ, Floyd ZE, Penn AL.
Am J Respir Cell Mol Biol 2008;38(5):532-540.
Accepted prior to April 7, 2008

Modulation of PPAR gamma stability and transcriptional activity in adipocytes by resveratrol.
Floyd ZE, Wang ZQ, Kilroy SG, Cefalu WT.
Metabolism 2008;57S:S32-S38. PMCID:PMC2585986.

PPARs, RXRs, and Stem Cells.
Floyd ZE, Gimble JM.
PPAR Res 2007;93578. PMCID:PMC2221637.

The Epigenetics of Adult (Somatic) Stem Cells.
Eilertsen K, Floyd ZE, Gimble JM.
Crit Rev Eukaryot Gene Expr 2008;18(3):189-206. PMCID:PMC2741686.

PPAR gamma AF-2 domain functions as a component of a ubiquitin-dependent degradation signal.
Kilroy SG, Zhang X, Floyd ZE.
Obesity 2009;17(4):665-73. PMCID:PMC2750041

Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolous monkeys.
Wang ZQ, Floyd ZE, Qin J, Liu X, Yu Y, Zhang XH, Wagner JD, Cefalu WT.
Diabetes 2009;58(7):1488-98. PMCID:PMC2699875.

The 4th Dimension and Adult Stem Cells: Can Timing Be Everything?
Gimble JM, Floyd ZE, Burnell BA.
Cell Biochem 2009;107(4):569-78. PMCID:PMC2761717.

High efficiency siRNA transfection of adipocytes in suspension.
Kilroy SG, Burk DH, Floyd ZE.
One 2009;4(9):e6940. PMCID:PMC2736387.

Fat Circadian Biology.
Gimble JM, Floyd ZE
J Appl Physiol. Invited Review 107:1629-1637, 2009. Review.

Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper: potential links between circadian mechanisms and obesity?
Gimble JM, Ptitsyn AA, Goh BC, Hebert T, Yu G, Wu X, Zvonic S, Shi XM, Floyd ZE.
Obes Rev 2009 Nov;10 Suppl 2:46-51. Review.

Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptoxotocin-diabetic rat model.
Shevalye H, Stavniichuk R, Xu W, Zhang J, Lupachyk S, Maksimchyk Y, Drel VR, Floyd ZE, Slusher B, Obrosova IG.
Biochem Pharmacol 2010;79:1007-1014. PMC Journal – In Process.

Regulation of adipogenesis by natural and synthetic REV-Erb ligands.
Kumar N, Rogers PM, Bhattacharyya G, Solt LA, Kamenecka T, Stayrook KR, Crumbely C, Floyd ZE, Gimble JM, Griffen PR, Burris TP.
Endocrinology 2010;151(7):3015-25. PMC Journal – In Process.

Human adenovirus 36 decreases fatty acid oxidation and increases de novo lipogenesis in primary cultured human skeletal muscle cells by promoting Cidec/FSP27 expression.
Wang ZQ, Yu Y, Zhang XH, Floyd ZE, Cefalu WT.
Int J Obes 2010;May 4. [Epub ahead of print]. PMC Journal – In Process.

Christopher Morrison, PhD

Increased hypothalamic PTP1B contributes to leptin resistance with age.
Morrison CD, White CL, Wang Z, Lee SY, Lawrence DS, Cefalu WT, Zhang ZY, Gettys TW.
Endocrinology 2007;148:433-440.

Neurobiology of nutrition and obesity.
Morrison CD, Berthoud HR.
Nutr Rev 2007;65:517-34.

Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism.
Morrison CD, Xi X, White CL, Ye J, Martin RJ.
Am J Physiol Endocrinol Metab 2007;293:E165-71.PMCID:PMC2596875

Leptin resistance and the response to positive energy balance.
Morrison CD.
Obesity 2007;15(3):539-43.

The brain, appetite, and obesity.
Berthoud HR, Morrison C.
Annu Rev Psychol 2008;59:55-92. Accepted prior to 4/7/2008.

Combustion-derived hydrocarbons concentrate in cytoplasmic lipid droplets of respiratory cells. Am
Murphy G Jr, Rouse RL, Polk WW, Henk WG, Barker SA, Boudreaux MJ, Floyd ZE, Penn AL.
Physiol Behav 2008;94: 660–663. PMCID:PMC2517010.

Effects of chromium picolinate on food intake and satiety.
Anton SD, Morrison CD, Cefalu WT, Martin CK, Coulon S, Geiselman P, Han H, White CL, Williamson DA.
Diabetes Technol Ther 2008;10:405-412. PMCID:PMC2753428.

Implications of crosstalk between leptin and insulin signaling during the development of diet induced obesity.
Morrison CD, Huypens P, Stewart LK, Gettys TW.
Biochim Biophys Acta 2009;1792:409-16. PMCID:PMC2713765.

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and independent mechanisms.
White CL, Whittington A, Barnes MJ, Wang Z, Xi X, Martin RJ, Bray GA, Morrison CD.
Am J Physiol Endocrinol Metab 2009;296:E291-9.PMCID:PMC2645015.

PPAR gamma AF-2 domain functions as a component of a ubiquitin-dependent degradation signal.
Kilroy SG, Zhang X, Floyd ZE.

Obesity 2009;17(4):665-73. PMCID:PMC2750041.

Leptin signaling in brain: A link between nutrition and cognition?
Morrison CD.
Biochim Biophys Acta 2009;1792:401-8. PMCID:PMC2670357.

Obesity and vulnerability of the CNS.
Bruce-Keller AJ, Keller JN, Morrison CD.
Biochim Biophys Acta 2009;1792:395-400. PMCID:PMC2699212.

Maternal obesity is necessary for the programming effect of a high-fat diet on offspring.
White CL, Purpera MN, Morrison CD.
Am J Physiol Regul Integr Comp Physiol 2009;296:R1464-72. PMCID:PMC2689819.

Effects of High Fat Diet on Cognition and Brain Oxidative Stress and Inflammation: Contributions of Maternal Diet.
White CL, Pistell PJ, Gupta S, Fernandez-Kim SO, Hise TL, Keller JN, Ingram DK, Morrison CD, Bruce-Keller AJ
Neurobiol Dis 2009;35:3-13. PMCID:PMC2699188.

Cognitive impairment following high fat diet consumption is associated with brain inflammation.
Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK, Bruce-Keller AJ.
J Neuroimmunol 2010;219:25-32. PMCID:PMC2823983.

NOX Activity in Brain Aging: Exacerbation by High Fat Diet.
Bruce-Keller AJ, White CL, Gupta S, Knight AG, Pistell PJ, Ingram DK, Morrison CD, Keller JN.
Free Radic Biol Med 2010;49:22-30. PMCID:PMC2875353.

Decreased food intake following overfeeding involves leptin-dependent and leptin-independent mechanisms.
White CL, Purpera MN, Ballard K, Morrison CD.
Physiol Behav 2010;100:408-16.PMCID:PMC2875678.

Innervation of skeletal muscle by leptin receptor-containing neurons.
Babic T, Purpera MN, Banfield BW, Berthoud HR, Morrison CD.
Brain Res 2010;1345:146-55. PMCID:PMC2897939.

Intersection between metabolic dysfunction, high fat diet consumption, and brain aging.
Uranga RM, Bruce-Keller AJ, Morrison CD, Fernandez-Kim SO, Ebenezer PJ, Zhang L, Dasuri K, Keller JN.
J Neurochem 2010;114:344-61. PMCID:PMC2910139.