About the Administrative Core
During the initial four years of support, the Pennington COBRE led an effort to enhance the research base in metabolic disease in Louisiana by recruiting and mentoring junior faculty who represent the next generation of scientists to power the discovery process. This goal was advanced through a sustained and highly integrated mentoring plan that resulted in attainment of significant new independent funding by our Project PIs. The complementary goal of building scientific infrastructure was achieved through a significant leveraging of institutional support that produced state of the art Genomics and Cell Biology and Bioimaging Core facilities. The collective efforts of the COBRE have enriched the scientific environment for metabolica disease research at the institution by enhancing the competitiveness and productivity of junior and senior faculty alike. The primary goals in the next funding cycle are to magnify the scientific impact of our newly established, state of the art infrastructure while continuing to expand the critical mass of funded investigators engaged in obesity/diabetes research within the institution. In the next cycle, our COBRE will support five projects from outstanding junior faculty employing a combination of cellular, molecular, and translational approaches to address questions ranging from neural mechanisms of glucose sensing and energy homeostasis, inflammatory mechanisms linked to adipogenesis, epigenetic programming in obesity, to regulation of mitochondrial biogenesis in adipocytes.